GEO series

Direct Reprogramming of Human Neural Stem Cells by OCT4

GSE15355 Homo sapiens Expression profiling by array 10 samples Submitted 2009/09/23 Platform GPL6883

Summary

Induced pluripotent stem (iPS) cells have been generated from mouse and human somatic cells by ectopic expression of the four transcription factors (OCT4, SOX2, c-MYC, KLF4). We previously reported that Oct4 alone is sufficient to directly reprogram adult mouse neural stem cells (NSCs) to iPS cells. Here, we report the generation of one-factor (1F) human iPS from human NSCs (1F hNiPS) by ectopic expression of Oct4 alone. 1F hNiPS cells resemble human embryonic stem cells (hESCs) in global gene expression profiles, epigenetic status and pluripotency in vitro and in vivo. These findings demonstrate that the transcription factor OCT4 is sufficient to reprogram human NSCs to pluripotency. 1F iPS cell generation will accelerate this field further towards understanding reprogramming and generating patient-specific pluripotent stem cells.

This dataset

Open GSE15355 in finder → Find more human microarray datasets →

Download

Direct links to NCBI, no account and no request form: the whole study as GSE15355_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 10 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA115771. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 19718018) ↗

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 10 more — browse all 10 samples with per-sample file links →

Similar datasets

GSE8977 Bone-marrow-derived mesenchymal stem cells promote breast cancer metastasis 22 samples
GSE28359 Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells 8 samples
GSE21244 Expression data from undifferentiated human pluripotent stem cells 7 samples
GSE7965 Blood and Adipose tissue samples 1722 samples
GSE20142 Primary human leucocyte RNA expression of unrelated Dutch individuals. 1240 samples
GSE194040 I-SPY2-990 mRNA/RPPA Data Resource: mRNA component 988 samples
GSE36133 Expression data from the Cancer Cell Line Encyclopedia (CCLE) 917 samples
GSE37069 Gene response to major burn injuries 590 samples

Search all human microarray datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.