Estrogen-mediated downregulation of HIF-1 signaling in B lymphocytes influences postmenopausal bone loss
RNA-seq (gene expression) · mouse · 28 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 28 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE163851_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA687752 and SRA study SRP298940. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 28 more — browse all 28 samples with per-sample file links →
- GSE271730 Differential but complementary roles of HIF-1α and HIF-2α in the regulation of bone homeostasis 9 samples shares hif-1, bone
- GSE278003 Single cell RNA sequencing of CD45+ immune cells from tumor and tumor-adjacent mammary adipose tissue in a postmenopausal breast cancer model of lean, obese, and weight loss Trem2+/+ and Trem2-/- mice 92 samples shares postmenopausal, loss
- GSE287619 Combination adjuvant improves influenza virus immunity by downregulation of immune homeostasis genes in lymphocytes 15 samples shares downregulation, lymphocytes
- GSE330528 Latexin deletion in the bone marrow niche suppresses leukemia via LIFR signaling downregulation and immune activation 8 samples shares downregulation, bone
- GSE196742 Mogrol attenuates osteoclast formation and bone resorption by inhibiting the TRAF6/MAPK/NF-κB signaling pathway in vitro and protects against osteoporosis in postmenopausal mice 6 samples shares postmenopausal, bone
- GSE325293 HIF-1α and HIF-2α transcription factors differentially regulate lung alveolar macrophage function 18 samples shares hif-1
- GSE317780 Effects of Hif-1α inhibition under hypoxic conditions on doxorubicin response in B16.F10 murine melanoma cells 15 samples shares hif-1
- GSE268827 scramble control and Hif-1a knockdown mESCs cultured under normoxia and two-day hypoxia 12 samples shares hif-1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.