Combination adjuvant improves influenza virus immunity by downregulation of immune homeostasis genes in lymphocytes
RNA-seq (gene expression) · mouse · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 15 samples: 5 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE287619_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1213831 and SRA study SRP558830. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 15 samples.
How we read this: 5 replicated groups read from 15 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8748957 PBS only, mouse 1 PBS only, mouse
- GSM8748958 PBS only, mouse 2 PBS only, mouse
- GSM8748959 PBS only, mouse 3 PBS only, mouse
- GSM8748960 PBS and antigen, mouse 1 PBS and antigen, mouse
- GSM8748961 PBS and antigen, mouse 2 PBS and antigen, mouse
- GSM8748962 PBS and antigen, mouse 3 PBS and antigen, mouse
- GSM8748963 AddaVax, mouse 1 AddaVax, mouse
- GSM8748964 AddaVax, mouse 2 AddaVax, mouse
- GSM8748965 AddaVax, mouse 3 AddaVax, mouse
- GSM8748966 CpG+MPLA, mouse 1 CpG+MPLA, mouse
- GSM8748967 CpG+MPLA, mouse 2 CpG+MPLA, mouse
- GSM8748968 CpG+MPLA, mouse 3 CpG+MPLA, mouse
- GSM8748969 IVAX, mouse 1 IVAX, mouse
- GSM8748970 IVAX, mouse 2 IVAX, mouse
- GSM8748971 IVAX, mouse 3 IVAX, mouse
- GSE299507 Combination with oxaliplatin improves abscopal effect of oncolytic virotherapy through reorganization of intratumoral macrophages II 30 samples shares combination, improves
- GSE328769 Alzheimer's disease associated Presenilin 2 N141I mutation impairs neuronal lipid homeostasis and mitochondrial dynamics through selective downregulation of the Golgi exchange factor Gbf1 16 samples shares downregulation, homeostasis
- GSE284500 Transcriptional profiling of hippocampus from a zQ175 KI mouse model of Huntington's disease treated with either HTT-10150 siRNA targeting full-length HTT or combination of HTT-634 and HTT-486 siRNAs targeting HTT1a 192 samples shares combination
- GSE342349 CT26 multi-tissue RNA-seq under immunotherapy combinations 72 samples shares combination
- GSE228579 Chronic stress disrupts hepatic homeostasis and accelerates liver cancer progression through ADRB2 signaling 66 samples shares homeostasis
- GSE318897 L-DOPA treatment promotes sustained neurovascular and synaptic homeostasis in the diabetic retina 53 samples shares homeostasis
- GSE338894 An orally active, gut-enriched AhR agonist demonstrates therapeutic efficacy in colitis through regulation of inflammation, barrier homeostasis, and fibrosis 50 samples shares homeostasis
- GSE242731 Class switch recombination regulation by extracellular vesicles mediated intercellular epigenomic signaling 48 samples shares combination
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.