PARP inhibition induces cytotoxicity in mESCs by activating endogenous retroviruses [ATAC-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 13 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 13 samples: 3 × KO_DMSO vs 3 × KO_Tal vs 3 × WT_DMSO vs 3 × WT_TalGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- PARP1 inhibition in naïve mouse embryonic stem cells induces viral mimicryNucleic acids research · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE166962_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA702478 and SRA study SRP306864. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 13 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM5089920 KO_DMSO_1 KO_DMSO
- GSM5089921 KO_DMSO_2 KO_DMSO
- GSM5089922 KO_DMSO_3 KO_DMSO
- GSM5089923 KO_Tal_1 KO_Tal
- GSM5089924 KO_Tal_2 KO_Tal
- GSM5089925 KO_Tal_3 KO_Tal
- GSM5089926 WT_DMSO_1 WT_DMSO
- GSM5089927 WT_DMSO_2 WT_DMSO
- GSM5089928 WT_DMSO_3 WT_DMSO
- GSM5089929 WT_Tal_1 WT_Tal
- GSM5089930 WT_Tal_2 WT_Tal
- GSM5089931 WT_Tal_2_resequenced
- GSM5089932 WT_Tal_3 WT_Tal
- GSE300887 Sequential Platinum and PARP Inhibition Enhances PD1 Immunotherapy Efficacy in Murine Brca2 Mutated Pancreatic Cancer [RNAseq_1] 13 samples shares parp, inhibition
- GSE249818 PRICKLE4 Underlies IDH mutant Tumors Resistance against PARP Inhibition 12 samples shares parp, inhibition
- GSE266686 Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity [ChIP-Seq] 32 samples shares inhibition, induces
- GSE306920 Newly Evolved Endogenous Retroviruses Prime the Ovarian Reserve for Activation [CUT&Tag] 22 samples shares retroviruses, endogenous
- GSE281151 Transient histone deacetylase inhibition induces cellular memory of gene expression and three-dimensional genome folding 259 samples shares inhibition, induces
- GSE313112 Inhibition of METTL3 by STC-15 induces RNA misprocessing that results in dsRNA formation and activates innate immunity [RNA-Seq MC38] 69 samples shares inhibition, induces
- GSE253444 Combining TIGIT blockade with MDSC inhibition hinders breast cancer bone metastasis by activating anti-tumor immunity 55 samples shares inhibition, activating
- GSE207029 Blockade of avb8 integrin synergizes with checkpoint inhibition to enhance anti-tumor immunity through Cxcl9-dependent augmentation of CD8+ T cell cytotoxicity 12 samples shares cytotoxicity, inhibition
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.