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Transcriptional profiling of microglia lacking Smad2/3

GSE168855 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/03/04 Platform GPL13112
Summary
Smad2/3 are canonical effector of TGFb signaling. This pathway is essential for microglial differentiation. We isolated Smad2/3-deficient microglia from mice and determined their transcriptional profiles. By comparing to control microglia, we observed changes in the expression of genes involved in macrophage function and lipid metabolism, which is consistent with the importance of these processes in microglial homeostasis. since microglia lacking Smad2/3 show an activated phenotype, these results provide insights into the transcriptional regulation of microglial function.
Published in
Radial glia integrin avb8 regulates cell autonomous microglial TGFβ1 signaling that is necessary for microglial identity
McKinsey GL, Santander N, Zhang X et al. · Nature communications 2025 · PMID 40121230 · doi:10.1038/s41467-025-57684-y
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Also filed as BioProject PRJNA714374 and SRA study SRP310544. Searching any of these in the dataset finder brings you back here.

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