N7-methylguanosine tRNA modification promotes tumorigenesis and chemoresistance through WNT/β-Catenin pathway in nasopharyngeal carcinoma
RNA-seq (gene expression) · human · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Nasopharyngeal carcinomaThis series is part of our curated briefing on it.
- Samples
- 20 samples: 3 × Vector_Polyribosome vs 3 × KO_Input vs 3 × KO_Polyribosome vs 2 × Vector_InputGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE169589_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA717060 and SRA study SRP312034. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 11 samples.
How we read this: 4 replicated groups read from 20 sample titles; they account for 11 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM5210379 Vector_Input_repl
- GSM5210380 Vector_Input_rep2 Vector_Input
- GSM5210381 Vector_Input_rep3 Vector_Input
- GSM5210382 Vector_Polyribosome_rep1 Vector_Polyribosome
- GSM5210383 Vector_Polyribosome_rep2 Vector_Polyribosome
- GSM5210384 Vector_Polyribosome_rep3 Vector_Polyribosome
- GSM5210385 KO_Input_rep1 KO_Input
- GSM5210386 KO_Input_rep2 KO_Input
- GSM5210387 KO_Input_rep3 KO_Input
- GSM5210388 KO_Polyribosome_rep1 KO_Polyribosome
- GSM5210389 KO_Polyribosome_rep2 KO_Polyribosome
- GSM5210390 KO_Polyribosome_rep3 KO_Polyribosome
- GSM5210391 Vector_Alkb_Treated_Input_for_TRAC-Seq
- GSM5210392 Knockout_Alkb_Treated_Input_for_TRAC-Seq
- GSM5210393 Vector_Alkb_and_NaBH4_Treated_TRAC-Seq
- GSM5210394 Knockout_Alkb_and_NaBH4_Treated_TRAC-Seq
- GSM5210395 Vector_Input_for_RiboSeq
- GSM5210396 Vector_RiboSeq
- GSM5210397 Knockout_Input_for_RiboSeq
- GSM5210398 Knockout_RiboSeq
- GSE186485 18S rRNA N6-methyladenosine (m6A) modification promotes tumorigenesis and chemoresistance via gain-of-function mutant p53 in nasopharyngeal carcinoma 16 samples same disease briefing · shares chemoresistance, nasopharyngeal, tumorigenesis, modification, promotes
- GSE305669 Reduced expression of UPF1 promotes tumor progression through stabilizing COX-2 mRNA in nasopharyngeal carcinoma 12 samples same disease briefing · shares nasopharyngeal, promotes
- GSE214026 Enhancer remodeling activates Notch signaling to confer chemoresistance in advanced nasopharyngeal carcinoma 10 samples same disease briefing · shares chemoresistance, nasopharyngeal
- GSE214023 Enhancer remodeling activates Notch signaling to confer chemoresistance in advanced nasopharyngeal carcinoma [ChIP-Seq] 6 samples same disease briefing · shares chemoresistance, nasopharyngeal
- GSE214025 Enhancer remodeling activates Notch signaling to confer chemoresistance in advanced nasopharyngeal carcinoma [RNA-Seq] 4 samples same disease briefing · shares chemoresistance, nasopharyngeal
- GSE162025 Tumour Heterogeneity and Intercellular Networks of Nasopharyngeal Carcinoma at Single Cell Resolution 40 samples same disease briefing · shares nasopharyngeal
- GSE150825 Comprehensive single-cell sequencing reveals the stromal dynamics and tumor-specific characteristics in the microenvironment of nasopharyngeal carcinoma 35 samples same disease briefing · shares nasopharyngeal
- GSE206245 Single-Cell and Spatial Transcriptome Analyses Reveal Tertiary Lymphoid Structures Linked to Tumour Progression and Immunotherapy Response in Nasopharyngeal Carcinoma 18 samples same disease briefing · shares nasopharyngeal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.