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Effect of Epstein-Barr Virus DNA on the Transcriptional Profile of BALB/c Mouse Peripheral Blood Mononuclear Cells

GSE171757 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/04/09 Platform GPL24247
Summary
To examine the effect of DNA from the Epstein-Barr Virus (EBV) on the transcriptional profile of mouse peripheral blood mononuclear cells (PBMCs), BALB/c mouse cells were isolated and cultured in the presence or absence of EBV DNA. RNA was extracted from these cells and then subjected to sequencing. We observed significantly enhanced expression of genes that play roles in proinflammatory processes including ones involved in autoimmune diseases such as rheumatoid arthritis.
Published in
An IL-17A-centric response to Epstein-Barr virus DNA mediated by dendritic Cell-T cell interactions
Shehab M, Hussein H, Fadlallah S et al. · Frontiers in molecular biosciences 2024 · PMID 38638687 · doi:10.3389/fmolb.2024.1243366
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Also filed as BioProject PRJNA720820 and SRA study SRP314176. Searching any of these in the dataset finder brings you back here.

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