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RNA sequencing for the gene expression profile changes of shPdgf-d and shControl mESCs

GSE172117 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/04/15 Platform GPL24247
Summary
In this study, by RNA sequencing, we found that Pdgf-d knockdown significantly downregulated differentiation associated genes, particularly those of vascular development and angiogenesis. MAPK/ERK signaling related genes level were repressed as well. Collectively, our work reveals that PDGF-D is a novel player in ESCs regulation and suggests potential application for PDGF-D in ESCs culture and vascular lineage derivation.
Published in
PDGFD switches on stem cell endothelial commitment
Lu W, Xu P, Deng B et al. · Angiogenesis 2022 · PMID 35859222 · doi:10.1007/s10456-022-09847-4
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Also filed as BioProject PRJNA722153 and SRA study SRP314936. Searching any of these in the dataset finder brings you back here.

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