Altering metabolism to program cell identity via NAD+ dependent deacetylation [RNA-seq]
RNA-seq (gene expression) · mouse · 30 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 30 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Altering metabolism programs cell identity via NAD(+)-dependent deacetylationThe EMBO journal · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE173532_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA725905 and SRA study SRP316790. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 30 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM5269362 Serum_LIF_rep1 (RNA-seq)
- GSM5269363 Serum_LIF_rep2 (RNA-seq)
- GSM5269364 Serum_LIF_rep3 (RNA-seq)
- GSM5269365 EMM_3h_rep1 (RNA-seq)
- GSM5269366 EMM_3h_rep2 (RNA-seq)
- GSM5269367 EMM_3h_rep3 (RNA-seq)
- GSM5269368 EMM_9h_rep1 (RNA-seq)
- GSM5269369 EMM_9h_rep2 (RNA-seq)
- GSM5269370 EMM_9h_rep3 (RNA-seq)
- GSM5269371 EMM_24h_rep1 (RNA-seq)
- GSM5269372 EMM_24h_rep2 (RNA-seq)
- GSM5269373 EMM_24h_rep3 (RNA-seq)
- GSM8380678 P10_2iL_1 P10_2iL
- GSM8380679 P10_2iL_2 P10_2iL
- GSM8380680 P10_2iL_3 P10_2iL
- GSM8380681 P10_EMM_1 P10_EMM
- GSM8380682 P10_EMM_2 P10_EMM
- GSM8380683 P10_EMM_3 P10_EMM
- GSM8380684 P10_SL_1 P10_SL
- GSM8380685 P10_SL_2 P10_SL
- GSM8380686 P10_SL_3 P10_SL
- GSM8380687 P20_2iL_1 P20_2iL
- GSM8380688 P20_2iL_2 P20_2iL
- GSM8380689 P20_2iL_3 P20_2iL
- GSM8380690 P20_EMM_1 P20_EMM
- GSM8380691 P20_EMM_2 P20_EMM
- GSM8380692 P20_EMM_3 P20_EMM
- GSM8380693 P20_SL_1 P20_SL
- GSM8380694 P20_SL_2 P20_SL
- GSM8380695 P20_SL_3 P20_SL
- GSE247845 FoxA1/2-dependent epigenomic reprogramming drives lineage switching in lung adenocarcinoma [RNA-Seq] 20 samples shares dependent, program, rna-seq
- GSE307669 Succinate-GPR91 signaling promotes cardiomyocyte metabolic reprogramming and NAD⁺ production to alleviate HFpEF 16 samples shares nad, program
- GSE274992 Splenic fibroblasts control marginal zone B-cell movement and function via two distinct Notch2-dependent regulatory programs 119 samples shares dependent, program
- GSE297451 Temporal and Context-Dependent Requirements for the Transcription Factor Foxp3 in Regulatory T Cell Development and Maintenance [RNA-seq] 70 samples shares dependent, rna-seq
- GSE278199 Microglia regulate cortical remyelination via ΤNFR1-dependent phenotypic polarization [scRNA-Seq] 45 samples shares dependent, rna-seq
- GSE255061 Phosphatase-independent activity of smooth-muscle calcineurin orchestrates a gene expression program leading to arterial hypertension 40 samples shares dependent, program
- GSE286519 Glucocorticoids unleash immune-dependent melanoma control through inhibition of the GARP/TGFβ axis [RNA-seq] 31 samples shares dependent, rna-seq
- GSE289309 RNA-seq profiling of mouse lung endothelial cells to investigate ENG-dependent and ENG-independent BMP9-induced target genes. 16 samples shares dependent, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.