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Pervasive subtypes of pancreatic ductal adenocarcinoma (PDA) and their differing response to therapy.

GSE17891 Mus musculus; Homo sapiens Expression profiling by array 62 samples Submitted 2011/04/01 Platform GPL8321Platform GPL570
Summary
Pancreatic ductal adenocarcinoma (PDA) carries a dismal prognosis and current treatments are only modestly effective. We present evidence that this variation is caused in part by recurrent, pervasive molecular differences between tumors. mRNA expression profiles measured using microdissected PDA clinical samples reveal three dominant subtypes of disease; epithelial, mesenchymal and acinar-like. The classical and quasi-mesenchymal subtypes are observed in human and mouse PDA cell lines. Importantly, responses to cytotoxics and KRAS depletion in human PDA cell lines differ substantially between subtypes, and in opposing directions. Integrated genomics implicate and functional studies support overexpression of the trancription factor GATA6 as a driver of the epithelial subtype. These results provide a molecular framework for evaluating the prospects of personalized treatment in PDA.
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Also filed as BioProject PRJNA120077. Searching any of these in the dataset finder brings you back here.

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