Localized PD-1 CAR T therapy reprograms neuroinflammation.
RNA-seq (gene expression) · mouse · 390 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 390 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE327497_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1451089 and SRA study SRP690525. Searching any of these in the dataset finder brings you back here.
The grouping that defines any comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Sample titles run AB10361 … AB22023 and carry no group information.
- GSM9257591 AB10361
- GSM9257592 AB10362
- GSM9257593 AB11353
- GSM9257594 AB11354
- GSM9257595 AB11355
- GSM9257596 AB11356
- GSM9257597 AB12142
- GSM9257598 AB12143
- GSM9257599 AB12144
- GSM9257600 AB12145
- GSM9257601 AB12146
- GSM9257602 AB12147
- GSM9257603 AB12148
- GSM9257604 AB12149
- GSM9257605 AB12150
- GSM9257606 AB12151
- GSM9257607 AB12152
- GSM9257608 AB12153
- GSM9257609 AB12154
- GSM9257610 AB12155
- GSM9257611 AB12156
- GSM9257612 AB12157
- GSM9257613 AB12161
- GSM9257614 AB12162
- GSM9257615 AB12163
- GSM9257616 AB12164
- GSM9257617 AB12165
- GSM9257618 AB12166
- GSM9257619 AB12167
- GSM9257620 AB12168
- GSM9257621 AB12169
- GSM9257622 AB12170
- GSM9257623 AB12171
- GSM9257624 AB12172
- GSM9257625 AB12173
- GSM9257626 AB12174
- GSM9257627 AB12175
- GSM9257628 AB12176
- GSM9257629 AB12177
- GSM9257630 AB12615
+ 350 more — browse all 390 samples with per-sample file links →
- GSE307471 Intratumoral bacteria are immunosuppressive and promote immunotherapy resistance in head and neck squamous cell carcinoma 33 samples shares car, therapy
- GSE292179 Priming with DNMT inhibitors potentiates PD-1 immunotherapy by triggering viral mimicry in relapsed/refractory NK/T-cell lymphoma 14 samples shares pd-1, therapy
- GSE17891 Pervasive subtypes of pancreatic ductal adenocarcinoma (PDA) and their differing response to therapy. 62 samples shares car, therapy
- GSE291268 Cardiac Radiotherapy-Induced Epigenetic Memory Underlies Electrophysiologic and Metabolic Reprogramming [ATAC-seq] 50 samples shares car, therapy
- GSE295309 Microbial cancer immunotherapy reprograms hematopoiesis to enhance myeloid-driven anti-tumor immunity 39 samples shares reprograms, therapy
- GSE246221 A Mouse Model for Metabolic Dysfunction-associated Steatotic Liver Disease and Hepatocellular Carcinoma [RNA-seq] 148 samples shares car
- GSE299215 E7386 enhances lenvatinib’s antitumor activity in preclinical models and human hepatocellular carcinoma. 44 samples shares car
- GSE294355 Dual function of DOT1L suppresses tumor intrinsic immunogenicity in Hepatocellular carcinoma [RNA-seq] 36 samples shares car
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.