GEO series

Expression profile of human T-ALL cell lines treated with DMSO or SAHM1

GSE18198 Homo sapiens Expression profiling by array 12 samples Submitted 2009/11/12 Platform GPL570

Summary

NOTCH proteins regulate signaling pathways involved in cellular differentiation, proliferation and death. Overactive Notch signaling as been observed in numerous cancers and has been extensively studied in the context of T-cell acute lymphoblastic leukemia (T-ALL) where more than 50% of pateints harbour mutant NOTCH1. Small molecule modulators of these proteins would be important for understanding the role of NOTCH proteins in malignant and normal biological processes. We were interested to measure the global changes in gene expression upon treatment of the human T-ALL cell lines HPB-ALL and KOPT-K1 with either vehicle alone (DMSO) or SAHM1, an alpha-helical hydrocarbon stapled peptide derived from the MAML1 co-activator protein.

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Direct links to NCBI, no account and no request form: the whole study as GSE18198_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 12 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA119553. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 19907488) ↗

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