Gene Expression Profiling in Diffuse Large B-Cell Lymphoma (DLBCL) Cell Lines Treated with Selinexor
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Diffuse large B-cell lymphomaThis series is part of our curated briefing on it.
- Samples
- 12 samples: 3 × OCI_LY3_con vs 3 × OCI_LY3_Selinexo vs 3 × SU_DHL6_con vs 3 × SU_DHL6_SelinexoGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A dual-mechanism model of Selinexor in DLBCL: p53 reactivation and metabolic reprogrammingJournal of translational medicine · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE283388_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1193560 and SRA study SRP549063. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8661276 OCI_LY3_con1 OCI_LY3_con
- GSM8661277 OCI_LY3_con2 OCI_LY3_con
- GSM8661278 OCI_LY3_con3 OCI_LY3_con
- GSM8661279 OCI_LY3_Selinexor1 OCI_LY3_Selinexo
- GSM8661280 OCI_LY3_Selinexor2 OCI_LY3_Selinexo
- GSM8661281 OCI_LY3_Selinexor3 OCI_LY3_Selinexo
- GSM8661282 SU_DHL6_con1 SU_DHL6_con
- GSM8661283 SU_DHL6_con2 SU_DHL6_con
- GSM8661284 SU_DHL6_con3 SU_DHL6_con
- GSM8661285 SU_DHL6_Selinexor1 SU_DHL6_Selinexo
- GSM8661286 SU_DHL6_Selinexor2 SU_DHL6_Selinexo
- GSM8661287 SU_DHL6_Selinexor3 SU_DHL6_Selinexo
- GSE252306 Comparing gene expression in ABT-199 (venetoclax) sensitive and resistant diffuse large B cell lymphoma cell (DLBCL) lines 12 samples same disease briefing · shares dlbcl, lymphoma, diffuse, large, lines
- GSE262641 Discovery of golcadomide (CC-99282) as a promising drug candidate for diffuse large B-cell lymphoma (DLBCL) 6 samples same disease briefing · shares dlbcl, lymphoma, diffuse, b-cell, large
- GSE280321 USP13 dictates RAN turnover and vulnerability to ferroptosis in diffused large B cell lymphoma (DLBCL) 4 samples same disease briefing · shares dlbcl, lymphoma, diffuse, large
- GSE262621 Gene expression profiling of HIV-associated diffuse large B-cell lymphomas from Malawi 70 samples same disease briefing · shares lymphoma, diffuse, b-cell, large
- GSE213555 Molecular and pathological characterisation of diffuse large B-cell lymphomas in children with Nijmegen breakage syndrome 41 samples same disease briefing · shares lymphoma, diffuse, b-cell, large
- GSE218750 TRAF3 loss-of-function Reveals the Non-Canonical NF-κB Pathway as a Therapeutic Target in Diffuse Large B-cell Lymphoma 24 samples same disease briefing · shares lymphoma, diffuse, b-cell, large
- GSE287333 Myeloid-derived suppressor cells exhibit distinct characteristics in bone marrow and blood of individuals with diffuse large B-cell lymphoma 19 samples same disease briefing · shares lymphoma, diffuse, b-cell, large
- GSE279610 Cell-cycle deregulation in diffuse large B-cell lymphoma promotes critical dependence on the cyclin-G associated kinase 18 samples same disease briefing · shares lymphoma, diffuse, b-cell, large
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.