GEO series
Characterization of excitotoxicity induced transcriptional dysregulation
GSE184681
Mus musculus
Expression profiling by high throughput sequencing
45 samples
2025/10/03
GPL19057
Summary
We describe the dysregulation of neuronal-activity dependent genes during the condition of toxic glutamate concentrations in primary hippocampal neurons. Genes differed in their response towards the loss of neuronal activity and the active shut-off of transcription. The most shut-off genes also show more direct synaptic function than the passively downregulated genes hinting to functional relevance of the shut-off mechanism. Findings were confirmed in an in vivo excitotoxicty model of Huntington´s disease.
Download
NCBI GEO page ↗
Paper (PMID 41339520) ↗
{# Names what the click gives you. "Open in finder" meant nothing to a
visitor who arrived from a search engine and has never seen the tool. #}
Find more
mouse RNA-seq datasets →
Similar datasets
- GSE292862 Modelling mouse embryogenesis from chemically induced totipotent stem cells 22 samples
- GSE185862 A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation 95 samples
- GSE304862 Semaglutide and exercise synergy in obesity: preserving muscle mass and uncovering organ crosstalk 209 samples
- GSE293315 MRPGRX2 Antagonist Treatment Prevents Inflammation and Disease in a Mouse Model of Atopic Dermatitis Dataset 2 35 samples
- GSE255837 Dysregulation of the Normal Wound Healing Cascade in Volumetric Muscle Loss Injury 30 samples
- GSE341948 Multi-tissue transcriptomic landscape reveals synergistic mechanisms of exercise and GLP-1 agonist in ameliorating diabetic phenotypes in db/db mice 12 samples
- GSE337190 CAR-NKT cells induce low cytokine release syndrome by targeting hyperinflammatory macrophages with mitigation from GM-SCF inhibition. 24 samples
- GSE306116 Caspase-3 Control of RNA Splicing and Mitochondrial Dynamics in Microglia during Parkinson’s Disease [RNA-Seq] 12 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.