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The cytokine receptor Fn14 regulates neuronal transcription during development and brain function in the adult [ATAC-seq]

GSE186631 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2024/10/25 Platform GPL19057
Summary
Signaling between the cytokine TWEAK and its receptor Fn14 is critical for neural circuit development in the postnatal brain. However, the downstream mechanisms through which TWEAK and Fn14 mediate synapse development have remained unclear. Here, we apply single-nucleus RNA-sequencing to Fn14 and TWEAK KO mice to characterize the genes that are regulated by this pathway in the developing dorsal lateral geniculate nucleus of the thalamus at single-cell resolution. We identify robust cohorts of genes that are misregulated in the absence of either Fn14 or TWEAK, providing insight into the transcriptional mechanisms through which cytokine signaling between microglia and neurons regulates a key phase of postnatal brain development that is driven by sensory experience.
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Direct links to NCBI, no account and no request form: the whole study as GSE186631_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA774841 and SRA study SRP343287. Searching any of these in the dataset finder brings you back here.

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