Skeletal muscle mRNA expression in 25 mice with or without genetic defects of mitochondrial fatty acid oxidation (Acadl and Acadvl knockout) using RNA sequencing.
RNA-seq (gene expression) · mouse · 25 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 25 samples: 22 distinct titles, 3 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A Multiomic Network Approach to Uncover Disease Modifying Mechanisms of Inborn Errors of MetabolismJournal of inherited metabolic disease · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE186648_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA774965 and SRA study SRP343392. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 25 sample titles: 22 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM5658233 gastroc.Het.Het.VL24.2
- GSM5658234 gastroc.Het.Het.VL27.1
- GSM5658235 gastroc.Het.Het.VL30.2
- GSM5658236 gastroc.Het.Het.VL8.1
- GSM5658237 gastroc.Het.KO.VL25.3
- GSM5658238 gastroc.Het.KO.VL30.1
- GSM5658239 gastroc.Het.KO.VL31.5
- GSM5658240 gastroc.Het.KO.VL36.3
- GSM5658241 gastroc.Het.WT.VL27.2
- GSM5658242 gastroc.Het.WT.VL28.1
- GSM5658243 gastroc.Het.WT.VL31.1
- GSM5658244 gastroc.Het.WT.VL32.2
- GSM5658245 gastroc.KO.Het.VL23.1
- GSM5658246 gastroc.KO.Het.VL23.2
- GSM5658247 gastroc.KO.Het.VL24.1
- GSM5658248 gastroc.KO.Het.VL25.2
- GSM5658249 gastroc.KO.Het.VL28.3
- GSM5658250 gastroc.KO.WT.VL25.1
- GSM5658251 gastroc.KO.WT.VL32.1
- GSM5658252 gastroc.KO.WT.VL37.1
- GSM5658253 gastroc.KO.WT.VL8.3
- GSM5658254 gastroc.WT.WT.VL26.3
- GSM5658255 gastroc.WT.WT.VL26.4
- GSM5658256 gastroc.WT.WT.VL38.2
- GSM5658257 gastroc.WT.WT.VL38.3
- GSE266882 Analysis of gastrocnemius muscle transcriptome from chow fed control and skeletal muscle HuR knockout mice with and without voluntary wheel running 56 samples shares skeletal, knockout, without, muscle
- GSE325832 RNA-seq analysis of skeletal muscle from control (Cre) and Terf2 knockout (KO) mice in gastrocnemius-plantaris-soleus (GPS) and tibialis anterior (TA) 35 samples shares skeletal, knockout, muscle
- GSE325919 Mitochondrial remodeling in skeletal muscle underlies exercise-induced reversal of age-associated functional decline in mice and humans 30 samples shares mitochondrial, skeletal, muscle
- GSE255246 Intrauterine hyperglycemia during late gestation caused mitochondrial dysfunction in skeletal muscle of male offspring through CREB/PGC1A signaling 10 samples shares mitochondrial, skeletal, muscle
- GSE267727 Transcriptome profiling of non-islet metabolic tissues in ~500 DO mouse liver, adipose, heart, and skeletal muscle tissue from mice fed high-fat, high-sugar diet [heart] 482 samples shares skeletal, muscle
- GSE253735 Loss of skeletal muscle Bmal1 +/- Exercise Training [Mouse liver, heart, inguinal white adipose and lung tissues 64 samples shares skeletal, muscle
- GSE273310 DELE1 mitochondrial integrated stress response to CHCHD10 G58R protein misfolding in striated muscle [RNA-seq] 64 samples shares mitochondrial, muscle
- GSE266918 RNA-seq expression analysis of liver, adipose, skeletal muscle, heart, and pancreatic islets from DO founder strain mice fed high-fat, high-sugar diet. [heart] 63 samples shares skeletal, muscle
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.