GEO series
Depletion of DIS3 from human cell lines
GSE188195
Homo sapiens
Expression profiling by high throughput sequencing
36 samples
2026/06/02
GPL24676
Summary
DIS3 is a 3’ to 5’ exoribonuclease responsible for degradation of multiple RNA targets. Most reports in human cells focus on its function in RNA surveillance in the nucleus. However, a small fraction of DIS3 can be also found in cytoplasm. Thus, the focus of this experiment was to identify the cytoplasmic targets of DIS3. Using rapid, auxin inducible, degradation of DIS3 protein and subcellular fractionation, we were able to identify RNA accumulated in cytoplasm of human cells upon DIS3 depletion. The raw data and counts for annotated and non-annotated transcripts resulting from this experiment are provided.
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