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RNAsequencing of plasma cells generated ex vivo upon 2 days of LPS stimulation on WT and Sec22B-KO plasma cells

GSE188452 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/10/29 Platform GPL24247
Summary
We report RNAseq data obtains from ex vivo generated plasma cell after 2 days of stimulation with LPS. We compare WT plasma cells to Sec22bB-KO plasma cells. Sec22b KO is specific of B cell lineage. We find over 6000 genes differentially regulated between both genotypes. Gene set enrichment analyses (GSEA) revealed that several pathways were significantly different between WT and Sec22bB-KO PCs.
Published in
Sec22b is a critical and nonredundant regulator of plasma cell maintenance
Bonaud A, Gargowitsch L, Gilbert SM et al. · Proceedings of the National Academy of Sciences of the United States of America 2023 · PMID 36595686 · doi:10.1073/pnas.2213056120
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Also filed as BioProject PRJNA778822 and SRA study SRP345132. Searching any of these in the dataset finder brings you back here.

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