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Transcriptome profiling reveals different expression pattern between beard and scalp hair follicle in androgenetic alopecia.

GSE189684 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/12/15 Platform GPL11154
Summary
Androgenetic alopecia (AGA) is a progressive dermatological disorder of scalp hair loss, while beard growth in AGA is normally unaffected. In an attempt to identify genes that contribute to the androgen-responsive phenotype, we performed a thorough transcriptome profiling of hair follicles (HFs) from frontal and occipital scalp, chin and armpit. Through this analysis, three specifiic different expressed genes(LGALS7B, FABP4, FOS) were identified using qPCR, immunofluorescence. The differences in the expression of these genes in cultured beard and frontal HF reflected less inflammation and immune response, more active keratinization and PPARs signaling in beard HFs compared to frontal HFs. This profiling results be used to understand the different molecular mechanism of hair growth between AGA beard and HF, and those provided a possibility for the enlarged beard phenotype and AGA treatment.
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Direct links to NCBI, no account and no request form: the whole study as GSE189684_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA784140 and SRA study SRP348196. Searching any of these in the dataset finder brings you back here.

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