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Microglia aging progresses through functional intermediate steps.

GSE190007 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/07/04 Platform GPL24247
Summary
Aged microglia contribute to maladaptive inflammation, but little is known about their progression from homeostasis to dysfunction during aging. Here, we analyze the spatiotemporal kinetics of microglial aging in the hippocampus. Spatially, the dynamics of age-related inflammatory changes in microglia vastly differ across adjoining regions. Using single cell RNA-Sequencing and in vitro approaches, we find that microglia aging proceeds progressively through functional intermediate states that are necessary for inflammatory activation.
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Direct links to NCBI, no account and no request form: the whole study as GSE190007_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA785575 and SRA study SRP348915. Searching any of these in the dataset finder brings you back here.

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