← BioTransfer GEO Dataset Finder
GEO series

Transcriptomic profiling of senescent human stromal cells upon medicinal intervention with dihydromyricetin

GSE190280 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/12/31 Platform GPL11154
Summary
Aging and age-related pathologies can be delayed by specifically targeting the senescence-associated secretory phenotype (SASP), a hallmark feature of senescent cells. Achieving the goal using natural or synthetic agents would have a tremendous impact on the quality of lifespan and burden of age-related chronic diseases. We report the potential of dihydromyricetin (DMY), a bioactive phytochemical constituent that can be found in natural plants such as Rattan tea extract (RTE), in targeting senescent cells via suppression of the SASP. This study demonstrates the efficacy of DMY as medicinal agent in controlling the influence of senescent human stromal cells and provides a strong rationale for its future use in aging intervention and geriatric medicine.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE190280_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA786574 and SRA study SRP349426. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 9 more — browse all 9 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.