Transcriptomic profiling of senescent human blood vessel cells upon medicinal intervention with ginkgo boliba extract or rattan tea extract

Aging and age-related pathologies can be delayed by specifically targeting the senescence-associated secretory phenotype (SASP), a hallmark feature of senescent cells. Achieving the goal using natural or synthetic agents would have a tremendous impact on the quality of lifespan and burden of age-related chronic diseases. We report the potential of ginkgo boliba extract (GBE), a commonly used dietary supplement and traditional herbal medicine for hundreds of years in China as an antioxidant and free radical scavenger, or rattan tea extract (RTE), a medicinal agent used for many years for the treatment of inflammation, fatty liver, tumor, diabetes and hyperlipidemia, in targeting senescent cells via suppression of the SASP. This study demonstrates the efficacy of GBE and RTE as medicinal products in controlling the influence of senescent human blood vessel cells and provides a strong rationale for their future use in aging control and geriatric medicine.