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Ablation of the Sost gene prevents hallmarks of calcific aortic valve disease in a high-cholesterol mouse model

GSE190295 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/12/01 Platform GPL24247
Summary
The purpose of this study was to understand the effect of sclerostin genetic ablation (gene: Sost) on aortic valve fibrocalcification in an aged, high-cholesterol diet mouse model. Sclerostin is a potent agent in bone remodeling. It both blocks Wnt-mediated osteoblast bone deposition and spurs RANKL-mediated osteoclast maturation and subsequent bone resorption. A monoclonal antibody was recently approved as a treatment for post-menopausal osteoporosis but clinical trials indicated potential cardiovascular side effects. This study aimed to begin to understand the potential role of sclerostin in the aortic valve.
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Direct links to NCBI, no account and no request form: the whole study as GSE190295_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA786602 and SRA study SRP349443. Searching any of these in the dataset finder brings you back here.

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