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Inorganic Biomaterials Shape the Transcriptome Profile to Induce Endochondral Differentiation

GSE193173 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/06/01 Platform GPL24676
Summary
We investigate cellular responses to traditional bioactive mineral-based nanomaterials, such as hydroxyapatite (nHA), whitlockite (nWH), silicon-dioxide (nSiO2), and the emerging synthetic 2D nanosilicates (nSi), on human mesenchymal stem cells (hMSCs). Specifically, using next-generation transcriptome sequencing (RNA-seq), we uncover key signaling pathways and transcriptome dynamics due to exposure to these inorganic nanomaterials. Whole-transcriptome sequencing identified a stabilized skeletal progenitor state in stem cells treated with nanosilicates that suggests endochondral differentiation of hMSCs, resulting in increased deposition of matrix mineralization compared with control or other treatment groups.
Published in
Inorganic Biomaterials Shape the Transcriptome Profile to Induce Endochondral Differentiation
· Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 · PMID 40285607 · doi:10.1002/advs.202505203
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Also filed as BioProject PRJNA795175 and SRA study SRP353821. Searching any of these in the dataset finder brings you back here.

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