Global gene expression profile of cortices from FUS and TDP mutant and control mouse
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 7 × FUS-mut vs 6 × TDP-mut vs 6 × TDP-WT vs 5 × FUS-WTGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Integrated analysis of transcriptomic and proteomic alterations in mouse models of ALS/FTD identify early metabolic adaptions with similarities to mitochondrial dysfunction disordersAmyotrophic lateral sclerosis & frontotemporal degeneration · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE196415_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA804866 and SRA study SRP359057. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 4 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM5880609 FUS-mut-Rep 1 FUS-mut
- GSM5880610 FUS-mut-Rep 2 FUS-mut
- GSM5880611 FUS-mut-Rep 3 FUS-mut
- GSM5880612 FUS-mut-Rep 4 FUS-mut
- GSM5880613 FUS-mut-Rep 5 FUS-mut
- GSM5880614 FUS-mut-Rep 6 FUS-mut
- GSM5880615 FUS-mut-Rep 7 FUS-mut
- GSM5880616 FUS-WT-Rep 1 FUS-WT
- GSM5880617 FUS-WT-Rep 2 FUS-WT
- GSM5880618 FUS-WT-Rep 3 FUS-WT
- GSM5880619 FUS-WT-Rep 4 FUS-WT
- GSM5880620 FUS-WT-Rep 5 FUS-WT
- GSM5880621 TDP-mut-Rep 1 TDP-mut
- GSM5880622 TDP-mut-Rep 2 TDP-mut
- GSM5880623 TDP-mut-Rep 3 TDP-mut
- GSM5880624 TDP-mut-Rep 4 TDP-mut
- GSM5880625 TDP-mut-Rep 5 TDP-mut
- GSM5880626 TDP-mut-Rep 6 TDP-mut
- GSM5880627 TDP-WT-Rep 1 TDP-WT
- GSM5880628 TDP-WT-Rep 2 TDP-WT
- GSM5880629 TDP-WT-Rep 3 TDP-WT
- GSM5880630 TDP-WT-Rep 4 TDP-WT
- GSM5880631 TDP-WT-Rep 5 TDP-WT
- GSM5880632 TDP-WT-Rep 6 TDP-WT
- GSE327960 Transcription profiles of mouse microglia isolated by FACS from WT and Grn KO animals, separated by lipofuscin levels [hex001110] 24 samples shares fus
- GSE211951 Pulmonary gene expression after ischemia reperfusion in young and old mice 24 samples shares fus
- GSE261792 Effect of Ethoxysanguinarine treatment on gene expression after Angiotensin-II infused C57BL/6 mice 18 samples shares fus
- GSE288185 TDP-43 directly inhibits RNA accumulation in neurites through modulation of RNA stability 86 samples shares tdp
- GSE246617 Cerebral vascular transcriptome profiling reveals intermittent fasting modulates chronic cerebral hypoperfusion-induced disease pathways. 78 samples shares fus
- GSE267650 Mouse kidney ischemia-reperfusion injury time course 57 samples shares fus
- GSE298751 Prussian blue nanoparticles targeting multiple PANoptosome-mediated PANoptosis for myocardial ischemia-reperfusion injury therapy 15 samples shares fus
- GSE280661 Lamp2-Flotillin-2 interaction enhances autophagosome-lysosome fusion to protect the septic heart in response to ILC2 13 samples shares fus
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.