Effect of Ethoxysanguinarine treatment on gene expression after Angiotensin-II infused C57BL/6 mice

The goals of this study is to identify the differential expressed genes in cardiac tissue of C57BL/6 mice with or without Angiotensin II (AngII) treatment, and compare the differential expressed genes in the cardiac tissue of Ang II infused C57BL/6 mice after Ethoxysanguinarine (ETH) treatment. Briefly, the mice (n=18) were randomly divided into 3 groups: control, AngII, AngII + ETH (n=6 for each group). Mice in Control and AngII groups were infused with saline and 500 ng/kg/min of AngII respectively, and orally administrated with saline; the mice in AngII + ETH group were infused with AngII (500 ng/kg/min) and orally administrated with 10 mg/kg /day of ETH daily for total 4 weeks. Then the cardiac tissue were used to identify differentially expressed genes among different groups.