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Genome-wide transcriptome analysis of VC and VHL-KO Caki-1 cells.

GSE196509 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/08/10 Platform GPL24676
Summary
To compare the transcriptomic changes mediated by VHL knockout in Caki-1 cells, we carried out the next-generation sequencing (NGS)-derived transcriptomic profiling. We found significant enrichment of gene signatures involving IFNa/b signaling in VHL-KO Caki-1 cells compared to control cells. Our analysis also demonstrated that VHL deficiency induced the expression of genes associated with the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway involved in sensing the cytoplasmic presence of double-stranded DNA (dsDNA).
Published in
VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway
Jiao M, Hu M, Pan D et al. · iScience 2024 · PMID 39050705 · doi:10.1016/j.isci.2024.110285
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Also filed as BioProject PRJNA805226 and SRA study SRP359236. Searching any of these in the dataset finder brings you back here.

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