GEO series
The role of EHMT2 in Uveal melanoma progression [EHMT2_Inhibitors]
GSE196624
Homo sapiens
Expression profiling by high throughput sequencing
18 samples
2025/11/14
GPL18573
Summary
EHMT2/G9a expression is elevated in many cancer types including uveal melanoma. Here in the present study, we have identified pharmacological inhibition of EHMT2/G9a in MP41 cells and Mel92.1 cells promote the sensitivity to NK cells in vitro. By keeping this in mind, we have performed RNA-seq of inhibition of EHMT2/G9a validated cells to identify the differentially regulated genes from various pathways that are responsible for promoting resistance to NK cell mediated cytotoxicity.
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Paper (PMID 41366520) ↗
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