Matched sampling reveals uncoupled phenotypic plasticity during metastasis formation in uveal melanoma
RNA-seq (gene expression) · human · 23 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Uveal melanomaThis series is part of our curated briefing on it.
- Samples
- 23 samples: 23 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Matched sampling reveals uncoupled phenotypic plasticity during metastasis formation in uveal melanomaiScience · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE317536_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1414427 and SRA study SRP666405. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 23 sample titles: 23 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9473915 Patient 1 (pUM)
- GSM9473916 Patient 2 (pUM)
- GSM9473917 Patient 3 (pUM)
- GSM9473918 Patient 5 (pUM)
- GSM9473919 Patient 9 (pUM)
- GSM9473920 Patient 4 (pUM)
- GSM9473921 Patient 6 (pUM)
- GSM9473922 Patient 7 (pUM)
- GSM9473923 Patient 10 (pUM)
- GSM9473924 Patient11 (pUM)
- GSM9473925 Patient 13 (pUM)
- GSM9473926 Patient 8 (pUM)
- GSM9473927 Patient 14 (pUM)
- GSM9473928 Patient 1 (mUM)
- GSM9473929 Patient 2 (mUM)
- GSM9473930 Patient 4 (mUM)
- GSM9473931 Patient 7 (mUM)
- GSM9473932 Patient 8 (mUM)
- GSM9473933 Patient 3 (mUM)
- GSM9473934 Patient 6 (mUM)
- GSM9473935 Patient 9 (mUM)
- GSM9473936 Patient 10 (mUM)
- GSM9473937 Patient 5 (mUM)
- GSE294950 Epigenetic library screen reveals novel targets for uveal melanoma 24 samples same disease briefing · shares melanoma
- GSE196624 The role of EHMT2 in Uveal melanoma progression [EHMT2_Inhibitors] 18 samples same disease briefing · shares melanoma
- GSE231395 PRAME induces genomic instability in uveal melanoma [RNA-seq] 15 samples same disease briefing · shares melanoma
- GSE287090 Exploration of tumor associated macrophages in patients with metastatic uveal melanoma by single cell RNAseq 12 samples same disease briefing · shares melanoma
- GSE317502 ATR Is a Critical Dependency Gene Supporting Uveal Melanoma Cell Survival 12 samples same disease briefing · shares melanoma
- GSE273527 Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma 9 samples same disease briefing · shares melanoma
- GSE233589 BET bromodomain inhibition potentiates ocular melanoma therapy by inducing cell cycle arrest 8 samples same disease briefing · shares melanoma
- GSE182942 ARL4C remarkably promotes the tumorigenesis of Uveal Melanoma and may represent a potential therapeutic target 6 samples same disease briefing · shares melanoma
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.