GEO series
Changes in Ikaros binding and histone-modifications upon oncogenic β-catenin activation [ChIP-Seq]
GSE196745
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
30 samples
2025/08/08
GPL17021GPL19057
Summary
We find that, in contrast to most cancer types, beta-catenin activation in preB-ALL cells supresses proliferation and leads to cell death. Proteomic analyses indicate that unlike in solid tumors beta-catenin interacts with Ikaros factors (IKZF1 and IKZF3) in pre-B cells. In order to examine the interaction between IKZF1/IKZF3 and beta-catenin we performed ChIPseq to assay chromatin state and TF binding in CTNNB1-GOF and IKZF1/3-LOF conditions.
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Paper (PMID 41507538) ↗
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