Changes in Ikaros binding and histone-modifications upon oncogenic β-catenin activation [ChIP-Seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 30 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 30 samples: 15 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Targeting β-catenin degradation with GSK3β inhibitors induces cell death in acute lymphoblastic leukemiaNature cancer · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE196745_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA807159 and SRA study SRP359900. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 30 samples.
How we read this: 15 replicated groups read from 30 sample titles; they account for 30 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM5900072 pooled_input_rep1 pooled_input
- GSM5900073 ERT2_IKZF-WT_H3K27ac_rep1 ERT2_IKZF-WT_H3K27ac
- GSM5900074 ERT2_IKZF-WT_H3K4me3_rep1 ERT2_IKZF-WT_H3K4me3
- GSM5900075 ERT2_IKZF-WT_IKZF1_rep1 ERT2_IKZF-WT_IKZF1
- GSM5900076 ERT2_IKZF-WT_IKZF3_rep1 ERT2_IKZF-WT_IKZF3
- GSM5900077 CRE_IKZF-WT_H3K27ac_rep1 CRE_IKZF-WT_H3K27ac
- GSM5900078 CRE_IKZF-WT_H3K4me3_rep1 CRE_IKZF-WT_H3K4me3
- GSM5900079 CRE_IKZF-WT_IKZF1_rep1 CRE_IKZF-WT_IKZF1
- GSM5900080 CRE_IKZF-WT_IKZF3_rep1 CRE_IKZF-WT_IKZF3
- GSM5900081 ERT2_IKZF-KO_H3K27ac_rep1 ERT2_IKZF-KO_H3K27ac
- GSM5900082 ERT2_IKZF-KO_H3K4me3_rep1 ERT2_IKZF-KO_H3K4me3
- GSM5900083 CRE_IKZF-KO_H3K27ac_rep1 CRE_IKZF-KO_H3K27ac
- GSM5900084 CRE_IKZF-KO_H3K4me3_rep1 CRE_IKZF-KO_H3K4me3
- GSM5900085 ERT2_IKZF-WT_H3K27ac_rep2 ERT2_IKZF-WT_H3K27ac
- GSM5900086 ERT2_IKZF-WT_H3K4me3_rep2 ERT2_IKZF-WT_H3K4me3
- GSM5900087 ERT2_IKZF-WT_IKZF1_rep2 ERT2_IKZF-WT_IKZF1
- GSM5900088 ERT2_IKZF-WT_IKZF3_rep2 ERT2_IKZF-WT_IKZF3
- GSM5900089 CRE_IKZF-WT_H3K27ac_rep2 CRE_IKZF-WT_H3K27ac
- GSM5900090 CRE_IKZF-WT_H3K4me3_rep2 CRE_IKZF-WT_H3K4me3
- GSM5900091 CRE_IKZF-WT_IKZF1_rep2 CRE_IKZF-WT_IKZF1
- GSM5900092 CRE_IKZF-WT_IKZF3_rep2 CRE_IKZF-WT_IKZF3
- GSM5900093 ERT2_IKZF-KO_H3K27ac_rep2 ERT2_IKZF-KO_H3K27ac
- GSM5900094 ERT2_IKZF-KO_H3K4me3_rep2 ERT2_IKZF-KO_H3K4me3
- GSM5900095 CRE_IKZF-KO_H3K27ac_rep2 CRE_IKZF-KO_H3K27ac
- GSM5900096 CRE_IKZF-KO_H3K4me3_rep2 CRE_IKZF-KO_H3K4me3
- GSM5900097 CRE_IKZF-WT_CTNNB1_rep1 CRE_IKZF-WT_CTNNB1
- GSM5900098 CRE_IKZF-WT_CTNNB1_rep2 CRE_IKZF-WT_CTNNB1
- GSM5900099 CRE_IKZF-KO_CTNNB1_rep1 CRE_IKZF-KO_CTNNB1
- GSM5900100 CRE_IKZF-KO_CTNNB1_rep2 CRE_IKZF-KO_CTNNB1
- GSM5900101 pooled_input_rep2 pooled_input
- GSE297574 H3K9 di-methylation dynamics underlies mouse minor zygotic genome activation [spike-in ChIP-seq of mESC] 64 samples shares activation, chip-seq
- GSE266022 Nrf2-mediated chromatin activation of hyperosmotic response genes attenuates heat-induced renal injury [ChIP-seq] 24 samples shares activation, chip-seq
- GSE314859 The degradation of maternal RNA-binding protein 4E-T regulates translational activation to ensure maternal-to-zygotic transition in mouse embryos 67 samples shares activation, binding
- GSE261221 Scaffolding element rewires genome architecture during differentiation at the Zfp608 locus (ChIP-Seq) 189 samples shares chip-seq
- GSE297309 SKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced gene [CUT&Tag] 108 samples shares activation
- GSE303384 Mechanism of maintenance and establishment of repression by the Mtg16 tumor suppressor [CUT&RUN, ChIP-Seq] 92 samples shares chip-seq
- GSE272524 Chromatin-dependent motif syntax defines differentiation trajectories [ChIP-seq] 76 samples shares chip-seq
- GSE294085 SIRT6 Overexpression Counteracts Chromatin Aging [ChIP-Seq] 74 samples shares chip-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.