GEO series
Gene expression changes in B-ALL upon oncogenic β-catenin activation [RNA-Seq]
GSE196767
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2025/08/08
GPL17021
Summary
We find that, in contrast to most cancer types, beta-catenin activation in preB-ALL cells supresses proliferation and leads to cell death. Proteomic analyses indicate that unlike in solid tumors beta-catenin interacts with Ikaros factors (IKZF1 and IKZF3) in pre-B cells. We performed RNA-seq in order to examine changes in expression upon beta-catenin activation in the presence and absence of Ikaros factors.
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Paper (PMID 41507538) ↗
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