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ATACseq of WT and Stat6 knockout Tfh21, Tfh214, and Tfh4 cells

GSE198060 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/03/04 Platform GPL13112
Summary
We report that Stat6-driven gene transcription regulates the transition from Tfh21 to Tfh4 cells, suppressing IL-21 production and promoting IL-4 secretion. We identified a cis-enhancer in the second intron of Il21 as a regulator of Tfh cell cytokine transition, via an effect of Stat6 on chromatin accessibility with repression of Il21 transcription. We conclude that Stat6 is necessary for coordinated regulation of IL-21 and IL-4 production by Tfh cells, leading to appropriate maturation of the germinal center B cell response.
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Also filed as BioProject PRJNA813550 and SRA study SRP362899. Searching any of these in the dataset finder brings you back here.

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