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Phf6 mutation induces leukemogenesis through altered chromatin state in mice (scRNA-Seq)

GSE198501 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/06/01 Platform GPL21493
Summary
To investigate the effect of PHF6 mutations in leukemogenesis, we generated Phf6R274X transgenetic(Tg) mice. Then we purified the Lineage-cKit+ cells from bone marrow of Phf6R274XTg and WT mice, and performed single cell RNA-seq to study hematopoietic stem cell differentiation trajectory.
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Direct links to NCBI, no account and no request form: the whole study as GSE198501_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA815652 and SRA study SRP363785. Searching any of these in the dataset finder brings you back here.

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