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Transcriptomic effects of ERRα repression in human 3D-cultured breast cancer cells.

GSE198923 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/03/04 Platform GPL18573
Summary
Estrogen Related Receptor α (ERRα) is a member of the nuclear receptor superfamily that acts as a transcription factor. In vivo, ERRα exerts diverse physiological functions such as modulation of bone mass and of energy metabolism. In addition, it plays a strong role in cancer progression. Transcriptional targets of ERRα and co-regulators of ERRα transcriptional activity have been identified using two-dimensional (2D) cell culture systems, which only partially reflect the three dimensional (3D) conditions under which a tumor develops. The aim of the study is to determine specific targets of ERRα during cancer progression and to identify new transcriptional co-regulators of ERRα under 3D conditions using a combination of bioinformatics, molecular and cellular biology approaches.
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Also filed as BioProject PRJNA817441 and SRA study SRP364772. Searching any of these in the dataset finder brings you back here.

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