GEO series
Single-Cell RNA-Seq Reveals Immunosuppressive Effects of Triple-Negative Breast Cancer–Derived Exosomes on NK Cell Responses
GSE303346
Homo sapiens
Expression profiling by high throughput sequencing
16 samples
2026/07/25
GPL34284
Summary
Triple-negative breast cancer (TNBC) is a highly aggressive and immunogenic subtype that lacks effective targeted therapies. Although tumor-derived exosomes are known to influence immune responses, their direct role in shaping human NK cell plasticity remains insufficiently characterized. In this study, we performed an integrative single-cell multiomic analysis of primary human NK cells following exposure to exosomes isolated from 17 genomically distinct TNBC cell lines. By combining single-cell transcriptomics, we identified conserved and subtype-specific immunoregulatory programs elicited by TNBC-derived exosomes.
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