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Single cell transcriptomic studies of an Antigen-Specific Dual Microparticle Treatment of a Mouse Model of Multiple Sclerosis

GSE199073 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/03/21 Platform GPL24247
Summary
A microparticle system using GMCSF, TGF-b, and VD3 along with disease specific antigen (Myelin Oligodendrocyte Protein) shows effiacy in treating a mouse model of multiple sclerosis, while GMCSF, TGF-b, and VD3 and irrelevant OVA antigen did not reduce scores. Here we show that pro-inflammatory and cell cycle genes are downregulated in multiple populations. scRNA-seq further revealed a reduction in antigen-presentation gene signature.
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Direct links to NCBI, no account and no request form: the whole study as GSE199073_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA818296 and SRA study SRP365082. Searching any of these in the dataset finder brings you back here.

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