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RNA sequencing of sorafenib-sensitive Huh-7 cells versus sorafenib resistant Huh-7/SR1 and Huh-7/SR2 cells

GSE200098 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/07/30 Platform GPL16791
Summary
Sorafenib is the global standard of care for patients with advanced hepatocellular carcinoma. It has marginal efficacy and patients invariably develop therapeutic resistance. The primary goal of this project was to comprehensively chratcerize the molecular profile of sorafenib resistant Huh-7/SR1 and Huh-7/SR2 cells compared to their parental counterpart Huh-7 cells, and discover potential new druggable targets which can overcome sorafenib resistance.
Published in
Inhibition of the Caveolin-1 pathway promotes apoptosis and overcomes pan-tyrosine kinase inhibitor resistance in hepatocellular carcinoma
Kabir TD, Beck S, Stuart LM et al. · Cell death & disease 2025 · PMID 40715090 · doi:10.1038/s41419-025-07887-4
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Also filed as BioProject PRJNA822938 and SRA study SRP367408. Searching any of these in the dataset finder brings you back here.

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