Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function [RNA-Seq]
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × RNA-Seq - Treg Ikzf1 conditional knockout ex vivo stimulated vs 3 × RNA-Seq - Treg Ikzf1 conditional knockout ex vivo vs 3 × RNA-Seq - Treg WT ex vivo stimulated vs 3 × RNA-Seq - Treg WT ex vivoGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Foxp3 depends on Ikaros for control of regulatory T cell gene expression and functioneLife · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE200178_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA823557 and SRA study SRP367608. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 6 samples read as cases, 3 as controls.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6019896 RNA-Seq - Treg Ikzf1 conditional knockout ex vivo stimulated 1 RNA-Seq - Treg Ikzf1 co…
- GSM6019897 RNA-Seq - Treg Ikzf1 conditional knockout ex vivo stimulated 2 RNA-Seq - Treg Ikzf1 co…
- GSM6019898 RNA-Seq - Treg Ikzf1 conditional knockout ex vivo stimulated 3 RNA-Seq - Treg Ikzf1 co…
- GSM6019899 RNA-Seq - Treg Ikzf1 conditional knockout ex vivo 1 RNA-Seq - Treg Ikzf1 co…
- GSM6019900 RNA-Seq - Treg Ikzf1 conditional knockout ex vivo 2 RNA-Seq - Treg Ikzf1 co…
- GSM6019901 RNA-Seq - Treg Ikzf1 conditional knockout ex vivo 3 RNA-Seq - Treg Ikzf1 co…
- GSM6019902 RNA-Seq - Treg WT ex vivo stimulated 1 RNA-Seq - Treg WT ex vi…
- GSM6019903 RNA-Seq - Treg WT ex vivo stimulated 2 RNA-Seq - Treg WT ex vi…
- GSM6019904 RNA-Seq - Treg WT ex vivo stimulated 3 RNA-Seq - Treg WT ex vi…
- GSM6019905 RNA-Seq - Treg WT ex vivo 1 RNA-Seq - Treg WT ex vi…
- GSM6019906 RNA-Seq - Treg WT ex vivo 2 RNA-Seq - Treg WT ex vi…
- GSM6019907 RNA-Seq - Treg WT ex vivo 3 RNA-Seq - Treg WT ex vi…
- GSE267967 Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for functional differentiation of Treg cells [RNA-seq] 26 samples shares foxp3, regulatory, rna-seq
- GSE305064 FOXP3 Expression Depends on Cell-Type Specific Cis-Regulatory Element and Transcription Factor Circuitry [mouse_Tconv_ChIP-seq] 15 samples shares foxp3, regulatory, depends
- GSE311963 CD38 endows local antigen-specific Foxp3+ Treg cells with stress resilience for compartmentalized control of CNS inflammation 68 samples shares foxp3, control
- GSE149674 Dynamic Foxp3-chromatin interaction controls tunable Treg cell function 94 samples shares foxp3, control
- GSE267882 Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for effector Treg cell differentiation [ChIP-Seq] 34 samples shares foxp3, regulatory
- GSE267881 Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for effector Treg cell differentiation [ATAC-Seq] 30 samples shares foxp3, regulatory
- GSE267884 Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for effector Treg cell differentiation [scMultiome] 16 samples shares foxp3, regulatory
- GSE268774 Lymph node macrophages drive immune tolerance and resistance to cancer therapy by expression of the immune-regulatory cytokine IL-33 [RNA-seq] 48 samples shares regulatory, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.