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Transcriptome Profiling of Heart Ageing Reveals Distinct Pathological Gene Network

GSE200741 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/01/29 Platform GPL13112
Summary
Age-related changes in cardiac homeostasis lead to myocardial dysfunction and cardiovascular diseases, which predict the healthspan of ageing. Age is a prominent risk factor for cardiac-related diseases. During ageing, the heart undergoes structural remodeling (increased cardiac weight and myocardial fibrosis) and functional decline (reduced diastolic and systolic functions), causing vulnerability of the heart to extra stress. Consequently, these pathological changes lead to increased cardiovascular mortality and morbidity in elderly adults. The underlying mechanism of cardiac ageing remains largely unexplored; and no pharmacological agent is currently available to improve or delay cardiac senescence.
Published in
Downregulation of MLF1 safeguards cardiomyocytes against senescence-associated chromatin opening
Lv J, Chen Q, Wang J et al. · Nucleic acids research 2025 · PMID 39657728 · doi:10.1093/nar/gkae1176
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Also filed as BioProject PRJNA826465. Searching any of these in the dataset finder brings you back here.

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