Gene expression changes in human thoracic and abdominal aortic aneurysm tissue
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 4 × Control sample vs 4 × TAA sample vs 4 × AAA sampleGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- SOX6 expression and aneurysms of the thoracic and abdominal aortaiScience · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE202267_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA835311 and SRA study SRP373746. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6107503 Control sample1 Control sample
- GSM6107504 Control sample2 Control sample
- GSM6107505 Control sample3 Control sample
- GSM6107506 Control sample4 Control sample
- GSM6107507 TAA sample1 TAA sample
- GSM6107508 TAA sample2 TAA sample
- GSM6107509 TAA sample3 TAA sample
- GSM6107510 TAA sample4 TAA sample
- GSM6107511 AAA sample1 AAA sample
- GSM6107512 AAA sample2 AAA sample
- GSM6107513 AAA sample3 AAA sample
- GSM6107514 AAA sample4 AAA sample
- GSE235161 Mitochondrial NAD+ deficiency in vascular smooth muscle impairs collagen III turnover to trigger thoracic and abdominal aortic aneurysm 42 samples shares abdominal, thoracic, aneurysm, aortic
- GSE220774 Side- and disease-dependent changes in human aortic valve cell population and transcriptomic heterogeneity determined by single-cell RNA sequencing 15 samples shares changes, aortic
- GSE86469 Single cell transcriptomics defines human islet cell signatures and reveals cell-type-specific expression changes in type 2 diabetes [single cell] 638 samples shares changes
- GSE251807 Investigation of gene expression changes in normal human dermal fibroblasts after exposure to bone marrow mesenchymal stromal cell secretome 32 samples shares changes
- GSE287627 Human Subcutaneous abdominal adipose tissue RNAseq - NYC sample 19 samples shares abdominal
- GSE334189 RNA-seq analysis of global gene expression changes in human FSHD immortalized myotubes following treatment with the BAZ1A inhibitor C06 18 samples shares changes
- GSE275870 Expression profiling of primary and metastatic oral squamous cell carcinoma identifies progression-associated transcriptome changes and therapeutic vulnerabilities 108 samples shares changes
- GSE303983 Molecular responses in abdominal subcutaneous adipose tissue after a session of endurance exercise: effects of exercise intensity 90 samples shares abdominal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.