DsbA-L deficiency attenuates LPS-induced acute kidney injury via NF-κB/AP-1 regulation of macrophage polarization
RNA-seq (gene expression) · mouse · 13 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 13 samples: 4 × WT-AKI vs 3 × Dsba-l-ko-AKI vs 3 × Dsba-l-ko-Naive-N vs 3 × WT- Naive-NGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE202753_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA837207 and SRA study SRP374731. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 13 samples.
How we read this: 4 replicated groups read from 13 sample titles; they account for 13 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6132367 Dsba-l-ko-AKI-320 Dsba-l-ko-AKI
- GSM6132368 Dsba-l-ko-AKI-156 Dsba-l-ko-AKI
- GSM6132369 Dsba-l-ko-AKI-381 Dsba-l-ko-AKI
- GSM6132370 WT-AKI-317 WT-AKI
- GSM6132371 WT-AKI-319 WT-AKI
- GSM6132372 WT-AKI-12 WT-AKI
- GSM6132373 WT-AKI-13 WT-AKI
- GSM6132374 Dsba-l-ko-Naive-N1 Dsba-l-ko-Naive-N
- GSM6132375 Dsba-l-ko-Naive-N2 Dsba-l-ko-Naive-N
- GSM6132376 Dsba-l-ko-Naive-N3 Dsba-l-ko-Naive-N
- GSM6132377 WT- Naive-N1 WT- Naive-N
- GSM6132378 WT- Naive-N2 WT- Naive-N
- GSM6132379 WT- Naive-N3 WT- Naive-N
- GSE319035 P21+TREM2+-Senescent Macrophages Fuel Inflammaging and Metabolic Dysfunction-Associated Steatotic Liver Disease [NAFLD_time_course] 77 samples shares nf, macrophage
- GSE306718 Macrophage Cluster of Differentiation 163 promotes post-infarction cardiac repair and preserves left ventricular function via osteopontin 37 samples shares nf, macrophage
- GSE250551 Targeting inflammation with chimeric antigen receptor macrophages using a signal switch 32 samples shares nf, macrophage
- GSE337190 CAR-NKT cells induce low cytokine release syndrome by targeting hyperinflammatory macrophages with mitigation from GM-SCF inhibition. 24 samples shares nf, macrophage
- GSE303772 Ontogenically distinct alveolar macrophages mediate cigarette smoke-induced inflammation and damage [RNA-Seq] 24 samples shares nf, macrophage
- GSE210798 Splenic CD169+Tim4+ Marginal Zone Metallophilic Macrophages Are Essential for Wound Healing and Resolution of Inflammation After Myocardial Infarction 24 samples shares nf, macrophage
- GSE309348 Whole transcriptome sequencing of UPEC-infected testis and epididymis (5d) following depletion of CX3CR1+ macrophages 18 samples shares nf, macrophage
- GSE282695 STAT3 regulates pathogen control and clearance in macrophages by reprogramming inflammation-induced microbial defense response 18 samples shares nf, macrophage
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.