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Next Generation Sequencing (NGS) for the identification of markers disregulated in B-ALL cells following activation with the agonist CD40 antibody.

GSE202862 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/07/25 Platform GPL18573
Summary
The goal of this study was to identify through NGS transcriptomic (RNAseq), transcripts up and down-regulated, following the i.v. treatment of B-ALL Patient-Derived Xenotransplanted (PDX) mice (two models; #1 and #2) with anti-CD40 agonist antibody.
Published in
CD40 Agonist on Patient-Derived Xenograft Mice for the Treatment of B-Cell Acute Lymphoblastic Leukemia
Bellaye PS, Georgievski A, Ballerini P et al. · Clinical cancer research : an official journal of the American Association for Cancer Research 2025 · PMID 39540842 · doi:10.1158/1078-0432.CCR-24-1391
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Direct links to NCBI, no account and no request form: the whole study as GSE202862_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA837569 and SRA study SRP374934. Searching any of these in the dataset finder brings you back here.

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