Premature neural differentiation in cerebral organoids derived from early-onset autism individuals in a birth cohort
RNA-seq (gene expression) · human · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 16 samples: 16 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Deficiency of FABP7 Triggers Premature Neural Differentiation in Idiopathic Normocephalic Autism OrganoidsAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE203201_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA839063 and SRA study SRP375728. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 16 sample titles: 16 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6161673 D0_IMR
- GSM6161674 D0_ASD
- GSM6161675 D6_IMR
- GSM6161676 D6_ASD
- GSM6161677 D12_IMR
- GSM6161678 D12_ASD
- GSM6161679 D30_IMR
- GSM6161680 D30_ASD
- GSM6161681 D60_IMR
- GSM6161682 D60_ASD
- GSM6161683 D100_IMR
- GSM6161684 D100_ASD
- GSM6793505 scRNA-seq of human brain organoids: day30 in vitro [D30_ASD1_4]
- GSM6793506 scRNA-seq of human brain organoids: day30 in vitro [D30_ASD2_3]
- GSM6793507 scRNA-seq of human brain organoids: day30 in vitro [D30_NC3_1]
- GSM6793508 scRNA-seq of human brain organoids: day30 in vitro [D30_NC1B_3]
- GSE269105 Investigation of Chimeric Transcripts Derived from LINE-1 and Alu Retrotransposons in Cerebellar Tissues of Individuals with Autism Spectrum Disorder (ASD) 13 samples shares individuals, derived, autism
- GSE263425 Modeling the Blood-Brain Barrier Formation and Cerebral Cavernous Malformations in human PSCs- and primary tissue-derived organoids 12 samples shares organoids, cerebral, derived
- GSE334500 Psychotropic-drug and neurotransmitter perturbation RNA-seq of human iPSC-derived cardiac and retinal organoids (ToxiPred) 96 samples shares organoids, derived
- GSE228249 Transcriptome analysis of primary human hepatocytes-derived organoids [RNA-seq] 82 samples shares organoids, derived
- GSE287174 Patient-Derived Meningioma Organoids: A Reliable Model for Studying Human Tumor Pathophysiology 65 samples shares organoids, derived
- GSE299171 Hypoimmunogenic hPSC-derived cardiac organoids for immune evasion and heart repair [bulkRNA-seq] 48 samples shares organoids, derived
- GSE267990 Mutant GFAP alters lineage commitment of neural organoids [AxDorganoids_bulk_experiment2] 47 samples shares organoids, neural
- GSE268518 Duodenal-derived organoids from MASH patients exhibit altered digestive homeostasis. 39 samples shares organoids, derived
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.