GEO series
Premature neural differentiation in cerebral organoids derived from early-onset autism individuals in a birth cohort
GSE203201
Homo sapiens
Expression profiling by high throughput sequencing
16 samples
2025/01/22
GPL24676
Summary
Diversity clinical phenotypes of autism spectrum disorders (ASD), caused by heterogeneity of genetic and environmental factors, hampered the investigation in uncovering pathological mechanisms. Here we generated ASD patient-cerebral organoids from induced pluripotent stem cells (iPSCs) that reprogramed from the early-onset ASD individuals at around 2 years old with common clinical diagnosis in a prospective birth cohort, which was excluded typical autistic mutations and environmental exposures.
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Paper (PMID 39556706) ↗
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