COP1 Deficiency in BRAFV600E Melanomas Confers Resistance to Inhibitors of the MAPK Pathway [NGS2569]
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- COP1 Deficiency in BRAF(V600E) Melanomas Confers Resistance to Inhibitors of the MAPK PathwayCells · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE203467_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA840919 and SRA study SRP376294. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6172698 WT [SAM24359722]
- GSM6172699 WT [SAM24359723]
- GSM6172700 WT [SAM24359724]
- GSM6172701 ETV1 KO [SAM24359725]
- GSM6172702 ETV1 KO [SAM24359726]
- GSM6172703 ETV1 KO [SAM24359727]
- GSM6172704 ETV5 KO [SAM24359728]
- GSM6172705 ETV5 KO [SAM24359729]
- GSM6172706 ETV5 KO [SAM24359730]
- GSM6172707 ETV1ETV4ETV5 KO [SAM24359731]
- GSM6172708 ETV1ETV4ETV5 KO [SAM24359732]
- GSM6172709 ETV1ETV4ETV5 KO [SAM24359733]
- GSE307773 Oncogenic MAPK signalling induces epithelial cell state change and therapeutic resistance in vivo [RNA-Seq] 175 samples shares mapk, resistance
- GSE307774 Oncogenic MAPK signalling induces epithelial cell state change and therapeutic resistance in vivo [scRNA-Seq] 29 samples shares mapk, resistance
- GSE252255 METTL3 deficiency aggravates hepatic ischemia/reperfusion injury in mice by activating the MAPK signaling pathway 8 samples shares mapk, deficiency
- GSE308102 Oncogenic MAPK signalling induces epithelial cell state change and therapeutic resistance in vivo 2 samples shares mapk, resistance
- GSE325262 Targeting ABL kinases to overcome melanoma immune evasion during MAPKi resistance 2 samples shares mapk, resistance
- GSE308130 Oncogenic MAPK signalling induces epithelial cell state change and therapeutic resistance in vivo III 1 samples shares mapk, resistance
- GSE308125 Oncogenic MAPK signalling induces epithelial cell state change and therapeutic resistance in vivo II 1 samples shares mapk, resistance
- GSE308133 Oncogenic MAPK signalling induces epithelial cell state change and therapeutic resistance in vivo IV 1 samples shares mapk, resistance
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.