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Transcriptomics provides novel insights into the regulatory mechanism of panax notoginseng derived exosome-like nanoparticles on HUVECs cells

GSE203636 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/05/16 Platform GPL24676
Summary
In current study, we observed that panax notoginseng derived exosome-like nanoparticles successfully promoted proliferation, significantly inhibited apoptosis and greatly facilitated migration in HUVECs, further highlighting the robust therapy effects of HIF1A-AS1 to cardiovascular diseases (CVD). Moreover, transcriptomics was implemented to uncover its underlying mechanism. A total of 276 differentially expressed genes (DEGs) were identified, with some of them enriched in apoptosis, migration and cell cycle related pathways. Intriguingly, some DEGs were annotated in vascular development or coagulation function pathways. In view of this, we suggested panax notoginseng derived exosome-like nanoparticles mediated the progression of CVD by not only regulating the function of HUVECs, but also altering vascular development or coagulation function. Lastly, RT-qPCR confirmed the veracity and reliability of RNA-sequencing results.
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Also filed as BioProject PRJNA841661 and SRA study SRP376717. Searching any of these in the dataset finder brings you back here.

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