H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs [ChIP-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 105 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 105 samples: 95 distinct titles, 10 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programsNature genetics · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE205245_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA844277 and SRA study SRP377944. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 105 sample titles: 95 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6209007 BT245, DMSO, CBX2
- GSM6209008 BT245, DMSO, RING1B
- GSM6209009 BT245, UNC4976, CBX2
- GSM6209010 BT245, UNC4976, RING1B
- GSM6209011 hNPC, CBX2
- GSM6209012 hNPC, H3K27me3
- GSM6209013 hNPC, H3K4me3
- GSM6209014 hNPC, Input
- GSM6209015 hiPSC, NSD1het, CBX2
- GSM6209016 hiPSC, NSD1het, CTCF
- GSM6209017 hiPSC, NSD1het, H2AK119ub
- GSM6209018 hiPSC, NSD1het, H3K4me3
- GSM6209019 hiPSC, NSD1het, RING1B
- GSM6209020 hiPSC, NSD1het, SUZ12
- GSM6209021 hiPSC, WT, CBX2
- GSM6209022 hiPSC, WT, CTCF
- GSM6209023 hiPSC, WT, H2AK119ub
- GSM6209024 hiPSC, WT, H3K27ac
- GSM6209025 hiPSC, WT, H3K27me3
- GSM6209026 hiPSC, WT, H3K36me2
- GSM6209027 hiPSC, WT, H3K36me3
- GSM6209028 hiPSC, WT, H3K4me3
- GSM6209029 hiPSC, WT, H3K9me3
- GSM6209030 hiPSC, WT, Input
- GSM6209031 hiPSC, WT, RING1B
- GSM6209032 hiPSC, WT, SUZ12
- GSM6209033 mESC, NSD1KO, CBX2, R1
- GSM6209034 mESC, NSD1KO, CBX2, R2
- GSM6209035 mESC, NSD1KO, RING1B, R1
- GSM6209036 mESC, NSD1KO, RING1B, R2
- GSM6209037 mESC, NSD1KO, inputForCBX2, R1
- GSM6209038 mESC, NSD1KO, inputForCBX2, R2
- GSM6209039 mESC, NSD1KO, inputForRING1B, R1
- GSM6209040 mESC, NSD1KO, inputForRING1B, R2
- GSM6209041 mESC, WT, CBX2, R1
- GSM6209042 mESC, WT, CBX2, R2
- GSM6209043 mESC, WT, RING1B, R1
- GSM6209044 mESC, WT, RING1B, R2
- GSM6209045 mESC, WT, inputForCBX2, R1
- GSM6209046 mESC, WT, inputForCBX2, R2
+ 65 more — browse all 105 samples with per-sample file links →
- GSE255572 Chromatin remodeler CHD7 regulates neurogenic gene expression via controlling chromatin accessibility and modifications of histone marks H3K27me3 and H3K4me3 34 samples shares h3k27me3, chromatin, regulate
- GSE249981 Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation. 70 samples shares prc1, canonical
- GSE289305 Alterations in chromatin architecture promote totipotent-like features in a DUX-dependent manner [RNA-Seq] 27 samples shares architecture, chromatin
- GSE294966 ChIP-seq for beta-catenin, EZH2, EED, KMT2B, H3K4me3, H3K27me3 and sequential chipseq 148 samples shares h3k27me3
- GSE260456 DOT1L provides transcriptional memory through PRC1.1 antagonism [RNA-seq] 180 samples shares prc1
- GSE218715 EZH2 gain-of-function mutations distort H3K27me3 landscapes and transform transcriptional responses to PRC2 inhibition [RNA-seq] 88 samples shares h3k27me3
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.