GEO series
EZH2 gain-of-function mutations distort H3K27me3 landscapes and transform transcriptional responses to PRC2 inhibition [RNA-seq]
GSE218715
Mus musculus; Homo sapiens
Expression profiling by high throughput sequencing
88 samples
2024/03/06
GPL24676GPL24247GPL17021
Summary
We have modelled several tumor-associated PRC2 mutations in a single isogenic system in order to reveal their comparative impacts on chromatin and transcription. We have also explored the link between EZH2 mutational status and abnormal H3K27 methylation in a unique longitudinal cohort of follicular lymphoma (FL) patient samples.
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Paper (PMID 38658543) ↗
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