H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 156 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 156 samples: 129 distinct titles, 26 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programsNature genetics · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE205249_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA844270 and SRA study SRP377943. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 156 sample titles: 129 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM6208806 BT245, K27M
- GSM6208807 BT245, KO
- GSM6208808 DIPGXIII, K27M
- GSM6208809 DIPGXIII, KO
- GSM6208810 HSJ019, K27M
- GSM6208811 HSJ019, KO
- GSM6208812 G477, WT
- GSM6208813 G477, K27M
- GSM6208814 hiPSC, WT
- GSM6208815 hiPSC, NSD1het
- GSM6208816 hNPC, wt
- GSM6208817 mESC, WT
- GSM6208818 mESC, NSD1KO
- GSM6208819 PFA4, hypoxia
- GSM6208820 PFA4, normoxia
- GSM6209007 BT245, DMSO, CBX2
- GSM6209008 BT245, DMSO, RING1B
- GSM6209009 BT245, UNC4976, CBX2
- GSM6209010 BT245, UNC4976, RING1B
- GSM6209011 hNPC, CBX2
- GSM6209012 hNPC, H3K27me3
- GSM6209013 hNPC, H3K4me3
- GSM6209014 hNPC, Input
- GSM6209015 hiPSC, NSD1het, CBX2
- GSM6209016 hiPSC, NSD1het, CTCF
- GSM6209017 hiPSC, NSD1het, H2AK119ub
- GSM6209018 hiPSC, NSD1het, H3K4me3
- GSM6209019 hiPSC, NSD1het, RING1B
- GSM6209020 hiPSC, NSD1het, SUZ12
- GSM6209021 hiPSC, WT, CBX2
- GSM6209022 hiPSC, WT, CTCF
- GSM6209023 hiPSC, WT, H2AK119ub
- GSM6209024 hiPSC, WT, H3K27ac
- GSM6209025 hiPSC, WT, H3K27me3
- GSM6209026 hiPSC, WT, H3K36me2
- GSM6209027 hiPSC, WT, H3K36me3
- GSM6209028 hiPSC, WT, H3K4me3
- GSM6209029 hiPSC, WT, H3K9me3
- GSM6209030 hiPSC, WT, Input
- GSM6209031 hiPSC, WT, RING1B
+ 116 more — browse all 156 samples with per-sample file links →
- GSE205246 H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs [RNA-seq] 25 samples shares h3k27me3, prc1, architecture, spreading, organizes, canonical, chromatin, regulate
- GSE269652 SP1 antagonizes H3K27me3 to shape chromatin landscapes for RNA polymerase II recruitment during gastrulation 106 samples shares h3k27me3, chromatin
- GSE278946 cPRC1.2 and CTCF-Mediated Transition from Poised to Active Chromatin Loops Drives Bivalent Gene Activation 43 samples shares prc1, chromatin
- GSE277417 Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation [CUT&TAG] 38 samples shares prc1, canonical
- GSE241338 Genome-wide interference of chromatin architecture and Mediator in transcriptional bursting and gene network regulation 250 samples shares architecture, chromatin
- GSE326190 Alterations in chromatin architecture promote totipotent-like features in a DUX-dependent manner. 47 samples shares architecture, chromatin
- GSE338103 Linker histone H1.0 and JUNB Interaction Maintains Lineage-Specific and Age-Dependent Chromatin Architecture to Safeguard Cell Identity [ATAC-seq] 14 samples shares architecture, chromatin
- GSE218717 EZH2 gain-of-function mutations distort H3K27me3 landscapes and transform transcriptional responses to PRC2 inhibition. 244 samples shares h3k27me3
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.