GEO series
Evaluating the presence of rare ERα-antagonism induced cells in WT tissues
GSE205577
Mus musculus
Expression profiling by high throughput sequencing
18 samples
2024/10/31
GPL24247
Summary
To examine the effects of ERα antagonism (giredestrant) on Esr1-wildtype and Esr1-mutant mammary glands, animals were treated with hormone pellets (E2, P4), then dosed daily with vehicle (MCT) or giredestrant (30 mg/kg, p.o.) for four days. Following dosing, individual mammary epithelial cell populations were FACS-isolated and sequenced. Rare giredestrant-induced novel cells (at least 1000 cells per sample) were collected from WT tissues and compared to mutant-induced novel cells.
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Paper (PMID 39805955) ↗
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