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TGF-β promotes colitis and cancer development in Smad4-deficient intestinal epithelium in a Yap-dependent manner (DSS)

GSE205910 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/06/01 Platform GPL24247
Summary
TO highlight an integral role of the TGF-β/Smad4 axis in restraining intestinal inflammation and suggest TGF-β or Yap signaling as potential therapeutic targets in inflammatory bowel disease patients with decreased Smad4 expression. We then performed gene expression profiling analysis using data obtained from RNA-seq of colonic epithelia cells derived from DSS treatment.
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Direct links to NCBI, no account and no request form: the whole study as GSE205910_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA848222 and SRA study SRP379734. Searching any of these in the dataset finder brings you back here.

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